Tesamorelin. The Only FDA Approved Peptide for Visceral Fat. And What the Research Says About Your Brain Too.

Hey everyone, welcome to Peptides with Michele, where I explained peptides like you're in fifth grade.

I've done the research so you don't have to.

Let's get into it.

Hello, welcome back to Peptides with Michele.

I'm Michele, and I'm so glad you're here.

Before I dive in, just a quick reminder, I'm not a doctor and never pretend to be.

Everything I share comes from real published medical research.

I do my homework and I have walked alongside hundreds of people on this journey.

That's my credibility, not a medical degree.

Real research and real results.

And as always, everything I share is for educational purposes only.

Please always consult your physician before starting anything new.

One quick thing before I get into today's topic.

If you are already curious about accessing peptides safely through a licensed telehealth provider with a real doctor supervising, this is exactly what I help people do.

Just DM me podcast on Instagram.

My handle is peptides with Michele.

That's Michele with 1L or you can e-mail me Michele at balance on the go.net.

I will personally walk you through what that looks like.

No pressure, no obligation, just a real conversation.

Let's get into it Today I'm covering A peptide that I've been wanting to talk about for a while.

It is one that I think is going to surprise a lot of you because unlike most of the compounds I cover on this podcast, this one actually has something that almost no other peptides has.

Full FDA approval, real phase three human clinical trials published in peer reviewed journals, real measurable outcomes in real human beings.

And it is something that I think is going to resonate with a lot of people listening rising right now.

It specifically targets visceral fat, that is the deep internal fat around your organs that is the most dangerous kind and the hardest kind to get rid of.

And it does something else that the research is now starting to reveal that is genuinely fascinating.

But I'm getting ahead of myself.

So today we are talking about Tesamorelin and I am going to get into what this actually is so and also where did it come from?

So Tesamorelin is a man made version of a hormone your body already produces naturally called growth hormone releasing hormone.

Your body makes this hormone in part of your brain called the hypothalamus, and what it does is send a signal to your pituitary gland that is the tiny gland at the base of your brain telling it to release growth hormone.

As we get older, our bodies naturally produce less of this signaling hormone, which means less growth hormone gets released, which effects everything from our body composition to our energy to how we recover.

So Tesamorelin does not inject growth hormone directly into your body.

Instead, it returns or it restores the signal.

It tells your own pituitary gland to do what it is supposed to do, release growth hormone the way it did when we were younger.

And that distinction is actually really important for safety, because working with your body's own natural system is very different from overriding it with synthetic growth hormone.

So here is your 5th grade version of what Tesamorelin actually does.

Think of your pituitary gland like a factory that makes growth hormone.

When you are young, your brain sends a strong signal to the factory and it produces plenty.

As you get older, that signal gets weaker and the factory slows down.

Tesamorelin is like turning the signal back up, not overriding the factory, not forcing it to produce more than it should, just restoring the signal to a more youthful level so the factory can do its job.

And when your body starts producing more growth hormone in its natural pulsatile way, meaning in natural pulses the way it was designed to, things start to change, especially around your visceral fat.

Now let me tell you what the research actually shows, and that is where Tesamorelin really stands apart from the peptides that I cover.

The research behind Tesamorelin is not animal studies or cell studies.

It is 2 large phase three human clinical trials.

These are the gold standard of clinical research.

Randomized blind placebo-controlled hundreds of participants.

Real people, real outcomes, real measurements, and what those trials found is remarkable.

Participants who received Tesamorelin saw an average reduction in visceral that of 15 to 20% / 26 weeks.

That is measured by CT imaging, not by how someone feels or how they look in the mirror.

Actual imaging showing actual fat reduction around the internal organs.

A 2026 analysis published in Obesity Research and Clinical Practice confirm these findings again, and a controlled 26 week trial found an average 10.9% reduction in visceral fat with Tesamorelin compared to 0.6% with placebo.

The difference is not settle.

Tesamorlin also improved waist circumference, waist to hip ratio and patient rated body image in those trials.

These are real measurable changes that people could see and feel.

OK, so if I, if that alone just resonates with you, if stubborn visceral fat or body composition is something you have been struggling with, definitely e-mail me and I can help you get in touch with someone that can help you prescribe it.

Now, I do want to tell you about the cognitive research because this is the part that I think is going to surprise you.

A 2012 study published in JAMA, the Journal of American Medical Association, one of the most respected journals medical journals in the world, found that Tesamorelin improved executive function and verbal memory in adults over 60.

Executive function is your ability to plan, focus, organize, and manage your time.

Verbal memory is your ability to remember words, conversations, and information.

These are two of the cognitive functions that decline most noticeably as we age.

And this was a real human study showing real, measurable improvement.

The connection makes sense when you understand the mechanism, which is the growth hormone plays a role not just in body composition, but in brain health and cognitive function.

Restoring more youthful growth hormone levels through Tesamorelin appears to have benefits that go well beyond what you can see in the mirror.

Now, I do want to be honest about a few things because I always am.

The FDA approved Tesamorelin specifically for reducing excess abdominal fat in adults with HIV associated with fat redistribution, and that is its approved indication.

Many providers prescribe it off label, meaning outside of that specific approved use for visceral fat reduction and metabolic health in the broader population.

Off label prescribing is completely legal and common in medicine, but I want you to you know the distinction.

There are also some important things your doctor needs to know before prescribing Tesamorelin because it increases growth hormone and a related hormone called IGF.

One.

Your doctor will monitor this, but people with active cancer are not candidates because of theoretical concerns about growth factors, and some people see mild changes in blood sugar, so metabolic monitoring is an important part of the protocol.

This is exactly why doctor supervision is not just recommended, it is essential.

Now I want to be honest about something else.

The research shows that when people stop taking Tesamorelin, visceral fat does tend to gradually return over time.

Tesamorelin works by stimulating your body's own growth hormone system, and when the stimulus is removed, your levels return to where they were before.

But here is what the research also shows.

How much fat returns and how quickly depends to significantly on the quality of the medication being used in the habits you build during your protocol.

People who use pharmaceutical grade medication from a certified pharmacy and use that time to build real nutritional habits tend to maintain their results far longer than those that do not.

Which is why I always say that peptides are a tool, not a shortcut.

The results you build during your protocol are yours to keep if you put in the work alongside it.

This is exactly the kind of conversation to have with your provider who knows your full picture before you start.

Tesamorelin is an injection.

Your provider will walk you through exactly what protocol is right for your specific situation.

And one more thing before we wrap and it is something I do say a lot, but peptides are powerful and they work because they work.

They need doctor supervision.

Please do not cut corners on this.

Your health is worth doing it right.

I've done so many episodes on this now.

If you do have questions, DM me on Instagram.

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If you want to learn how I personally access peptides including Tesamorelin through licensed Telehealth provider with real doctor supervision, DM me podcast on Instagram peptides with Michele or e-mail me Michele Michele at balance on the go.net.

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Talk soon, friends.